The LADEE (pronounced lad-ee) lunar mission is scheduled to launch from Wallops Island, Virginia tonight at 11:27 PM EDT aboard a Minotaur V rocket. The ascent will be low to the horizon but should be visible towards the south-east for viewers in the NE United States.
Launch coverage will be on NASA TV. Here is some additional info about viewing the launch. Have a look at the purple colored map on the first link to get an idea of how high it will be as seen from your location. Its not all that high (relatively speaking) so you'll need a good SSE horizon. If you can get to the Atlantic coast or position yourself NW of a large lake that might be best. The weather looks fantastic for the launch tonight, and the evening timing is good. Because its at night it'll be easier to see the bright flame from the engine. A fist held at arm's length subtends about 10 degrees, so its going to be 1-2 fists high at max. Get the lowest horizon you can find. In New England you'll want to look due south.
With Orbital Sciences Corp contracted to launch resupply missions to the ISS from Wallops VA over the next couple of years there could be more opportunities like this, although well positioned night launches might be rare. Poke your head out tonight before bed and have a look. For photographers, set up on a tripod or prop and set your camera for a long exposure. Set the gain/ISO high, and take a few long practice shots to see how the light levels look. Follow NASA TV online to keep up with the status so you know when to pull the trigger. The launch video there should be interesting too.
Viewing guide:
http://www.universetoday.com/104515/how-to-see-the...
Additional info:
http://www.nasa.gov/mission_pages/ladee/main/index...
NASA TV online:
http://www.nasa.gov/multimedia/nasatv/index.html#....